![]() Some of these studies involve very large protein assemblies of many subunits. The cryo-EM field is slowly moving to allow many high-resolution maps produced in one project or study 12, 13. In the past five years, more than 1,000 protein structures have been determined at 4 Å resolution or better in the EM databank using single-particle reconstruction 7, 8, 9, 10, 11. Due to the averaging of many identical copies of the same macromolecule in single-particle reconstruction, the achieved resolution can be very high, even beyond 2 Å resolution 5, 6. When the copies of the macromolecule/assembly are different from each other, cryo-electron tomography (cryo-ET) can be carried out (the sample needs to be rotated and images at different rotating angles will be collected). There is a density value associated with each voxel (volume pixel) of the map. A 3D density map is represented as values on a 3D grid. When there are many identical copies of the macromolecule in the sample (different views of the macromolecule are present in the collected images), single particle reconstruction can be carried out to reconstruct the 3D density map of the macromolecules. Briefly, samples are fast frozen in liquid-nitrogen cooled liquid ethane and imaged in an electron microscope at cryogenic temperatures. Cryo Electron Microscopy (Cryo-EM)Ĭurrently, one of the leading techniques for determining the atomic structure of proteins is cryo-electron microscopy (cryo-EM) 2, 3, 4. Therefore, learning the details of a protein’s 3D structure is a prerequisite to understanding its biological function. Despite each protein being composed from a combination of the same 20 naturally occurring amino acids, a protein’s functionality is mainly derived from its unique three-dimensional (3D) shape. ![]() From molecule transportation, to mechanical cellular support, to immune protection, proteins are the central building blocks of life in the universe 1. Proteins perform a vast array of functions within organisms. The source code and demo of this research has been published at. The C-CNN also achieved an average root-mean-square deviation (RMSD) of 1.24 Å on a set of 50 experimental density maps which was tested by the Phenix based fully automatic method. This method accurately predicted 88.9% (mean) of the Cα atoms within 3 Å of a protein’s backbone structure surpassing the 66.8% mark achieved by the leading alternate method (Phenix based fully automatic method) on the same set of density maps. It outperformed several state-of-the-art prediction methods including Rosetta de-novo, MAINMAST, and a Phenix based method by producing the most complete predicted protein structures, as measured by percentage of found Cα atoms. This method was tested on 50 experimental maps between 2.6 Å and 4.4 Å resolution. Finally, a novel quality assessment-based combinatorial algorithm was used to effectively map protein sequences onto Cα traces to obtain full-atom protein structures. A helix-refinement algorithm made further improvements to the α-helix SSEs of the backbone trace. A specialized tabu-search path walking algorithm was used to produce an initial backbone trace with Cα placements. ![]() This method is largely automatic and only requires a recommended threshold value for each protein density map. The cascaded-CNN is a semantic segmentation image classifier and was trained using thousands of simulated density maps. This model predicts secondary structure elements (SSEs), backbone structure, and Cα atoms, combining the results of each to produce a complete prediction map. The cascaded-CNN (C-CNN) is a novel deep learning architecture comprised of multiple CNNs, each predicting a specific aspect of a protein’s structure. Here we introduce a deep learning model that uses a set of cascaded convolutional neural networks (CNNs) to predict Cα atoms along a protein’s backbone structure. However, predicting the backbone trace of a protein has remained a challenge on all but the most pristine density maps (<2.5 Å resolution). Recent advances in this field have allowed for atomic resolution. Cryo-electron microscopy (cryo-EM) has become a leading technology for determining protein structures. ![]()
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You are in the correct place then. ![]() ![]() ![]() And there’s nothing to indicate that this piece might have been done as a cover for AMAZING ADVENTURES or any other title–everything we see indicates that it was intended from the start for FANTASTIC FOUR #1Ĭomparing this stat to the published cover, you can see that a lot of attention was paid to the bystanders on the right side. As you’d expect, the four word balloons were lettered directly onto the board before it was inked. And the paste-up of Sol Brodsky’s logo and of all of the type on the FEATURING box is plain to see. Notations at the top indicate that the cover was being produced for the JULY SCHEDULE and that the issue number and cover date should be #1 NOV. Sadly, there’s not a whole lot additional to see here. I also saved a version where I adjusted the brightness and contrast, giving us a better view of the places where white-out was used to make corrections, of paste-ups and other such evidence. Lee and Martin couldn’t stop fiddling with things. But this is why so many Marvel reprints of the early stories have cover reproductions that vary a bit from the actual published books. ![]() They’d make last-minute changes right as the cover was meant to be heading out the door, typically in the service of visual clarity. Both Martin Goodman and Stan Lee were notoriously picky about the covers on their titles–often to the point of craziness. This would have been shot from the original art before the issue went off to press–but also before every last bit of fine-tuning was done to the piece. And having done that, I thought I’d reproduce it here, so that we can look at it and see what, if anything, it further tells us about the development of the issue. I’ve seen it before, but never thought to grab a copy of it for myself. The reason I’m doing this piece is that working on this book gave me access to Marvel’s in-house stat of the cover to FANTASTIC FOUR #1 again. 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A more proximal fracture site has a higher probability of non-union, which is why it has been suggested to define proximal fractures as those within the proximal fifth of the scaphoid. 19 Even though proximal pole fractures are incorporated within the Herbert and Mayo classification they lack a common definition. For comparison, the Mayo classification has a somewhat higher inter-observer reliability than the Herbert and Russe systems. 18 It provides a straight morphologic description that we find practical for clinical use. The Mayo classification that we use at our institution is essentially based on fracture location, and provides an appendix on factors attributable to instability. 17 Vertical oblique fractures, which account for < 5% of scaphoid fractures, are highly unstable, which is why internal fixation is generally recommended. ![]() Russe classified scaphoid fractures based on fracture plane orientation into transverse, horizontal oblique and vertical oblique fractures. We find that such an approach may lead to considerable overtreatment. 15, 16 All bi-cortical fractures, except for fractures of the tubercle, are considered unstable and candidates for internal fixation. The most frequently used classification system is Herbert’s classification which is based on expected fracture instability. Available classification systems today are all based on radiographs. The aim of this review is to present an algorithm for diagnosis and treatment of acute scaphoid fractures.įracture classification adds important information for treatment and expected outcome. In cases of suspected scaphoid fracture where the initial radiographs are negative, magnetic resonance imaging (MRI) is recommended for diagnostics, while computed tomography (CT) has proven more reliable and accurate in the assessment of scaphoid fracture characteristics and union. It is well known that scaphoid fractures can be difficult to diagnose on initial radiographs. 3 However, in the case of the non-displaced scaphoid waist fracture, which is the most common among scaphoid fractures, it has been suggested that union can occur after just four to six weeks of immobilization. The serious consequences of non-union, such as progressive degenerative changes and carpal collapse, the so-called SNAC (scaphoid non-union advanced collapse) wrist have for patients, typically young and active, resulted in a restrictive treatment regime with immobilization from eight to 12 weeks. 1, 2 Scaphoid fractures are notorious for being difficult to diagnose as well as to achieve fracture union. ![]() Previous studies have shown that a scaphoid fracture is the most common fracture among patients with post-traumatic radial-sided wrist pain. 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![]() ![]() ![]() While on one hand, Stan Lee was the one who came closest to any form of a crossover with his cameo in Teen Titans Go! To The Movies, there hasn’t been an interaction between the two multiverses on the big screen. Each company would publish two issues of the miniseries, thus the title difference between issues 1 and 4 as DC vs. The speculation of this crossover is still very new since James Gunn is yet to initiate his work as the CEO from 1st November 2022. DC) is a comic book miniseries intercompany crossover published by DC Comics and Marvel Comics from April to May 1996. Now, seeing the direction where DC might be heading off, it is very likely to see the franchise shake hands with Marvel and mix and match the superheroes as well as the villains.Īlso Read: Is James Gunn Making Henry Cavill’s Man of Steel 2? Suicide Squad Director in Talks With WB for Secret DC Project A Marvel And DC Crossover Could Happen But, Do Fans Really Want It? Red Hood and The Winter Soldier have each other’s backs in the comics Having already covered both Marvel Comics and DC Comics, whats next Well sorry Image and Dark Horse fans, but this category deals. James Gunn has a long history with both Marvel and DC. The X-Men have had multiple comics over the years, with many first issues. Spider-Man and Batman: Disordered Minds sees Batman’s nemesis, the Joker, teaming up with the most murderous rogue Peter Parker’s ever faced Carnage. James Gunn Teases Marvel-DC Crossover Talk, 'Id Be Lying To Say We Havent Discussed It'. It's not uncommon to see actors, producers, directors, and writers move from the DC Universe to the Marvel Universe on screen. The Amazing Spider-Man’ (1976) Photo: Marvel Comics/DC Comics 1976’s Superman vs. Speaking of crossovers involving Bruce Wayne, another Marvel figurehead crossed paths with Batman when a terrifying team-up emerged. Published Marvel and DC Comics have a complicated rivalry, but in the source material, they have crossed over in a variety of ways across their storied history. The comics have seen a lot of crossovers between Marvel and DC, from Hawkeye joining the Justice League to Superman picking up Mjolnir and using Captain America’s shield the team-ups have been endless. 6 Spider-Man and Batman: Disordered Minds. 3, Gunn indicated that a Marvel and DC crossover would definitely 'be cool', but wouldnt happen anytime. Warning Spoilers ahead for Dark Crisis: Big Bang 1 ahead The Big Two haven't interacted in a while, but it seems a crossover between DC Comics and Marvel is on the horizon. While speaking to Deadline at the red carpet premiere for Guardians of the Galaxy Vol. ![]() Lynn, who transmigrated, became a student at the Academy of Mutants, possessing the ability to wield magic. Complete list of comic crossovers between DC Comics characters and Marvel characters. Richtman had allegedly also foretold the involvement of Noah Centineo being included in Black Adam as Atom Smasher and has been a reliable source for a long time. It’s been years since DC and Marvel have had a crossover, but a discovery of the Flash’s in Dark Crisis: Big Bang 1 hints that one may be coming. (Marvel x DC Comics) In the wondrous world of comics, superheroes are infinitely awesome, but mutants with superpowers often endure great tragedy. Nova and Green Lantern fighting together in the comics ![]() ![]() ![]() If you spend a lot of time with friends or family on your back porch, you’ll want it to be a cozy spot for everyone to enjoy. ![]() How do I decorate my backyard patio in the Fall? Consider a topiary to fit into the corner of your deck or porch that brings some sophistication to the theme.ħ. Your outdoor space is guests’ first introduction to your home, so taking the time to organize fall items like burlap sacks, gourds, pinecones, and faux fall color leaves will add that seasonal flair to your home. The fall season is prime time for exercising your decoration skills in curb appeal, and a fall patio is a perfect place. How do I decorate my front deck in the Fall? String lights are also a beautiful way to light up your deck at night and are an easy DIY way to brighten up your other decorations. Some items you might already have to get your deck ready for Fall: a doormat for the door that connects your deck to the indoors, faux pumpkins to pull out once the leaves start to change, and a fire pit for huddling around when the nights get chilly. Keeping it simple is one route that keeps away the headache of doing too much in terms of decoration. White pumpkins and cornstalks are also great ways to bring the farm feel to your deck. Decorating doesn’t always have to be about doing something new, but when done right, having some traditional fall flowers and pumpkins will give you room to explore different orientations and pieces. Take the stunning change of colors in nature to your deck by incorporating the quintessential fall staples: mums and pumpkins. Old wooden chairs, small hay bales, and antique farm tools or furniture can add a little homelike character to your outdoors and look beautiful through December! You’re likely to find any number of farmhouse decorations at a local thrift or craft store. In addition, fall wreaths, Halloween decorations, and rustic lanterns are great to always have on hand, and adding gourds and seasonal flowers will enhance the Fall look of your deck.įall is a great opportunity to bring a rustic and barnyard feel to your deck with some farmhouse-style decor. Starting with the essential Fall must-have decorations will really enhance your deck’s appearance and save you time each year so that finding fresh orange pumpkins will be your only worry. Adding a side table and spreading planters will fall flowers like mums and sunflowers, add bright colors, and bring more life to your seating area! You can also decorate below your second story deck with an under-deck ceiling to make a cozy seating area that’s out of the elements. Start with a farmhouse bench topped with weather-resistant fabric pillows, layer rattan wicker, or any outdoor rug underneath to make a great spot for sitting on cool fall evenings. Check out these 10 tips for adding a little seasonal spice to your deck that you can use year after year. Pumpkins, fall flowers, and rustic antiques can bring a colorful warmth to your front porch, outdoor deck, or even cozy up the nook space underneath. Autumn in its full swing is the perfect time to spruce up the outdoor spaces of your home with some seasonal decorating. ![]() ![]() ![]() At least in Definitely, Maybe, the self-reflection of Ryan Reynolds’ love life as a politically woke yuppie New Yorker is partially framed from his 11-year-old daughter’s own point of view. If the episodes were an email asking for your attention, then the subject line is simply “Hello.”ĭarby and the narrator’s point of views are so singular and hackneyed it gets boring very quickly. We are simply teased with a scene of a pregnant Darby walking down a street in New York. This sets up the expectation that not only will Darby’s love life be full of ups and downs, it also implies that her love story contains nothing out of the ordinary. The show starts with a (loosely) scientific statement about love for “the average person”: how many times we fall in love, how many relationships we have and how many end with heartbreak. The inclusion of a narrator is charming at best, but unnecessary at its worst because the show seems so self-explanatory Darby’s narrated (and lengthy) backstory seems to have little to do with her modern-day self, and the bit about early 20th-century birth control in episode three doesn’t have much to do with anything. (Darby and Augie alone probably deserve a two-hour film). I can live with all of these things, if only to watch Kendrick charismatically tumble through her love life, but meaningful relationships condensed into 30-minute episodes feel like a disservice to such supposedly seminal points in Darby’s life. Gee, where have I seen these train wrecks before? (In fact, it’s Sara and her half-in, half-out interracial relationship who seems to have the more interesting story so far). reality when Augie comes back into the picture. Episode three introduces a greasy-haired bagel aficionado who has OCD about doing chin-ups (a casual humblebrag of 100 a day) with obvious warning signs Darby chooses to ignore (he keeps a second phone for his ex-girlfriend’s voicemails), and there’s some sort of brief treatise on Instagram vs. The second episode is similar, with Darby striking up a relationship with her former boss via casual sex, only to break up because of differences in age (he’s old, she’s not), socioeconomic habits (he’s rich, she’s not) and an ex-wife (she’s charming, she’s not). A lesson for Darby: if your boyfriend’s Knicks fandom lives and dies with Linsanity, he is either a morally hollow bandwagoner or deeply troubled and in need of immediate medical attention. Things don’t end well, of course, because first relationships usually end that way, and we hit all the goalposts: an instant attraction leading to a one-night stand, a time-consuming sequence about modern-day dating/texting etiquette (easily the worst part) and an eventual breakup because one of them ends up prioritizing their career instead. Augie ( Jin Ha) is a budding writer for Politico, and is basically a very woke version of a millennial professional and someone who you should automatically like much more than a lawyer or a finance guy. The first episode begins in 2011 with Darby falling in love for the first time. Her best friend is Sara ( Zoë Chao), who is loyal and supportive and everything an on-screen best friend should be, and they live together in a modest apartment. She is played by Anna Kendrick at her Kendrickian best: the smart, sweet and devoted girlfriend, with occasional bouts of insecurity and social awkwardness that only she can pull off without cringe. Every character, line and scene feels like a derivative of something else, and worse, be so mainstream and singular in its point of view that it fails to really say anything to a wider audience.ĭarby Carter is a young, single, everyday girl in New York ( the city of young, single, everyday people), her personality punctuated by a pastel Fjällräven backpack that has become so ubiquitous among today’s youth. If you’ve seen romantic comedies then you probably know what’s coming, and it’s with some disappointment through the first three episodes that it has yet to make a lasting impression. HBO Max’s first romcom sitcom, Love Life, is an anthology with each season telling the story about one particular individual’s first relationship to their (hopefully) last. ![]() They say love is a universal language, but that doesn’t mean it should be totally devoid of original thought. ![]() ![]() Masks required.Īttend the opening reception (everyone welcome)Ĭome and see an exhibition of fine craft with a twist. NBCCD’s Drawing Studio intends to ‘Pull Back the Curtain’ on this process in an exhibition of the same name at the George Fry Gallery with works from all college studios, opening Decemfrom 4-6pm, and running Monday-Friday, 10am – 4pm, until January 17, 2023. Your bowl, scarf, business card, jeans, and necklace started as a scribble. It’s the early drafts of an article the ingredients of a tasty treat. Further, exploring the pedagogy of art education posed additional thought and consideration to the teachers for their future practice and incorporation of the work of art, which is active, therefore not the same as the product of art into their classroom.PULL BACK THE CURTAIN - a drawing exhibitionĭrawing is vital for design work. The participants followed Dewey’s theory of knowledge in order to actively contribute to their own practice as well as contributing to the field of education. Reflections included themes ranging from pedagogy, planning, to self-improvement. Challenges from teaching art included budget, curriculum, and training. ![]() The small case study (n = 9) created individual narratives of each participant’s experience. Bricolage was employed to interpret meanings and analyze findings. Teachers were observed for one art lesson, to create a foundation to their everyday activity followed by a reflective discussion of the observation. The foundation of the research relies on Dewey’s theory of knowledge (experience + reflection = new knowledge). The heuristic foundation of this research is a reflective-formative style of inquire that is delicately entwined in the practice of language. The research follows hermeneutic phenomenology as it explains and gives voice to the lived experience. The research project was designed to understand the lived experience of general elementary teachers teaching art when they are minimally trained and art education is devalued in schools and educational policy. Qualitatively created frameworks, like those of the Studio Habits of Mind, can be used to inform our understanding of creative behavior in various disciplines. We argue that the creative thinking occurring during fashion design bears strong resemblances to that which occurs in the art studio-classroom. We found abundant evidence of all eight of these thinking dispositions in all portions of the show. An entire season of the show (14 episodes) was transcribed and coded for the presence of eight Studio Habits of Mind. Our source of data was footage from a popular reality television show, Project Runway, in which nascent fashion designers are given garment design challenges. Our focus is on " habits of mind " (thinking dispositions) used during the creative process, and the categories we used were those of the eight Studio Habits of Mind observed in visual arts classrooms (Hetland et al., 2007, 2013). We examine creativity from a qualitative process rather than a quantitative product perspective. The study’s findings and their implications for future research and practice concluded this study. The wide variety of professional development experiences was noted and the high degree to which the professional development experiences were found to be beneficial was extensive. ![]() Conditions that supported and eroded a sense of teacher self-efficacy were examined and the effects reviewed. Surprisingly, prior arts experiences showed little to no significant correlation. A high degree of correlation was found between the following: studio habits and the teacher self-efficacy factors that impacted teachers’ decisions to attend an arts professional development and between the total number of professional development hours and arts integration. The study utilized four aspects of the work on studio habits: observe, envision, explore, and reflect (Hetland, Winner, Veenema, & Sheridan, 2007, 2013). Ii Allison Kleinsteuber DecemEducational Leadership THE IMPACT OF PROFESSIONAL DEVELOPMENT IN THE ARTS UPON HABITS OF MIND AND TEACHER EFFICACY Abstract This study employed a concurrent exploratory mixed-methods approach to discern the impact professional development in the arts had upon habits of mind and teacher self-efficacy. ![]() |
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